SCOPe 2.04: Domain d3jzka_: 3jzk A:

Lineage for d3jzka_ (3jzk A:)

1. Root: SCOPe 2.04

2. Class a: All alpha proteins [46456] (285 folds)

3. Fold a.42: SWIB/MDM2 domain [47591] (1 superfamily)
   core: 4 helices: open bundle; capped by two small 3-stranded beta-sheets
   duplication: consists of two structural repeats

4. Superfamily a.42.1: SWIB/MDM2 domain [47592] (2 families)
   binds to the transactivation domain of human p53

5. Family a.42.1.1: SWIB/MDM2 domain [47593] (5 proteins)
   Pfam PF02201

6. Protein MDM2 [47594] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [47596] (41 PDB entries)

8. Domain d3jzka_: 3jzk A: [178930]
   automated match to d1rv1a_
   complexed with yin

Details for d3jzka_

PDB Entry: 3jzk, 2.1 Å

PDB Description: crystal structure of MDM2 with chromenotriazolopyrimidine 1

PDB Compounds: (A:) E3 ubiquitin-protein ligase Mdm2

SCOPe Domain Sequences for d3jzka_:

Sequence; same for both SEQRES and ATOM records:

>d3jzka_ a.42.1.1 (A:) MDM2 {Human (Homo sapiens) [TaxId: 9606]}
qipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrlydekqqhivyc
sndllgdlfgvpsfsvkehrkiytmiyrnlvvv

Timeline for d3jzka_:

• d3jzka_ first appeared in SCOPe 2.01
  
• d3jzka_ appears in SCOPe 2.03
  
• d3jzka_ appears in SCOPe 2.05
  
• d3jzka_ appears in the current release, SCOPe 2.08