SCOPe 2.03: Domain d3jvra_: 3jvr A:

Lineage for d3jvra_ (3jvr A:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cell cycle checkpoint kinase chk1 [64404] (1 species)
   CaMK group; CAMKL subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [64405] (70 PDB entries)

8. Domain d3jvra_: 3jvr A: [178846]
   automated match to d1ia8a_
   complexed with agx

Details for d3jvra_

PDB Entry: 3jvr, 1.76 Å

PDB Description: characterization of the chk1 allosteric inhibitor binding site

PDB Compounds: (A:) Serine/threonine-protein kinase Chk1

SCOPe Domain Sequences for d3jvra_:

Sequence, based on SEQRES records:

>d3jvra_ d.144.1.7 (A:) Cell cycle checkpoint kinase chk1 {Human (Homo sapiens) [TaxId: 9606]}
avpfvedwdlvqtlgegaygevqlavnrvteeavavkivdmkravdcpenikkeicinkm
lnhenvvkfyghrregniqylfleycsggelfdriepdigmpepdaqrffhqlmagvvyl
hgigithrdikpenlllderdnlkisdfglatvfrynnrerllnkmcgtlpyvapellkr
refhaepvdvwscgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplal
lhkilvenpsaritipdikkdrwynkplkkg

Sequence, based on observed residues (ATOM records):

>d3jvra_ d.144.1.7 (A:) Cell cycle checkpoint kinase chk1 {Human (Homo sapiens) [TaxId: 9606]}
avpfvedwdlvqtlgeevqlavnrvteeavavkivdmenikkeicinkmlnhenvvkfyg
hrreiqylfleycsggelfdriepdigmpepdaqrffhqlmagvvylhgigithrdikpe
nlllderdnlkisdfglatvfrynnrerllnkmcgtlpyvapellkrrefhaepvdvwsc
givltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplallhkilvenpsari
tipdikkdrwynkplkkg

Timeline for d3jvra_:

• d3jvra_ first appeared in SCOPe 2.01
  
• d3jvra_ appears in SCOPe 2.02
  
• d3jvra_ appears in SCOPe 2.04
  
• d3jvra_ appears in the current release, SCOPe 2.08