SCOPe 2.06: Domain d3in4a_: 3in4 A:

Lineage for d3in4a_ (3in4 A:)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein beta-secretase (memapsin) [50671] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50672] (281 PDB entries)
   Uniprot P56817 58-446 ! Uniprot P56817 60-447

8. Domain d3in4a_: 3in4 A: [178436]
   automated match to d1fkna_
   complexed with bx2

Details for d3in4a_

PDB Entry: 3in4, 2.3 Å

PDB Description: Bace1 with Compound 38

PDB Compounds: (A:) Beta-secretase 1

SCOPe Domain Sequences for d3in4a_:

Sequence, based on SEQRES records:

>d3in4a_ b.50.1.2 (A:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
sfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqls
styrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnweg
ilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmiig
gidhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlp
kkvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfr
itilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavs
achvhdefrtaavegpfvtldmedcgy

Sequence, based on observed residues (ATOM records):

>d3in4a_ b.50.1.2 (A:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
sfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqls
styrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnweg
ilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfvlasvggsmiiggidhsl
ytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfea
avksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfritilpq
qylrpvdcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsachvhdefrtaave
gpfvtldcgy

Timeline for d3in4a_:

• d3in4a_ first appeared in SCOPe 2.01
  
• d3in4a_ appears in SCOPe 2.05
  
• d3in4a_ appears in SCOPe 2.07
  
• d3in4a_ appears in the current release, SCOPe 2.08