SCOPe 2.05: Domain d3ikab_: 3ika B:

Lineage for d3ikab_ (3ika B:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
   PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [82796] (65 PDB entries)
   Uniprot P00533 702-1018

8. Domain d3ikab_: 3ika B: [178368]
   automated match to d1m14a_
   complexed with 0un; mutant

Details for d3ikab_

PDB Entry: 3ika, 2.9 Å

PDB Description: crystal structure of egfr 696-1022 t790m mutant covalently binding to wz4002

PDB Compounds: (B:) Epidermal growth factor receptor

SCOPe Domain Sequences for d3ikab_:

Sequence, based on SEQRES records:

>d3ikab_ d.144.1.7 (B:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
eapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkan
keildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqylln
wcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggkv
pikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqp
pictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptdsn
fyralmdeedmddvvdadeyl

Sequence, based on observed residues (ATOM records):

>d3ikab_ d.144.1.7 (B:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
eapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkan
keildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqylln
wcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglaklaeekeyhaeggkvpi
kwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppi
ctidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermtdsnfyralmd
eevvdadeyl

Timeline for d3ikab_:

• d3ikab_ first appeared in SCOPe 2.01
  
• d3ikab_ appears in SCOPe 2.04
  
• d3ikab_ appears in SCOPe 2.06
  
• d3ikab_ appears in the current release, SCOPe 2.08