SCOPe 2.08: Domain d3ik3a1: 3ik3 A:229-513

Lineage for d3ik3a1 (3ik3 A:229-513)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Abelsone tyrosine kinase (abl) [56166] (2 species)
   PTK group; Abl subfamily; non-membrane spanning protein tyrosine kinase

7. Species Mouse (Mus musculus) [TaxId:10090] [56167] (16 PDB entries)

8. Domain d3ik3a1: 3ik3 A:229-513 [178360]
   Other proteins in same PDB: d3ik3a2, d3ik3b2
   automated match to d1opjb_
   complexed with 0li; mutant

Details for d3ik3a1

PDB Entry: 3ik3, 1.9 Å

PDB Description: ap24534, a pan-bcr-abl inhibitor for chronic myeloid leukemia, potently inhibits the t315i mutant and overcomes mutation-based resistance

PDB Compounds: (A:) Proto-oncogene tyrosine-protein kinase ABL1

SCOPe Domain Sequences for d3ik3a1:

Sequence, based on SEQRES records:

>d3ik3a1 d.144.1.7 (A:229-513) Abelsone tyrosine kinase (abl) {Mouse (Mus musculus) [TaxId: 10090]}
spnydkwemertditmkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaa
vmkeikhpnlvqllgvctreppfyiiiefmtygnlldylrecnrqevsavvllymatqis
sameylekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwtap
eslaynkfsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpekv
yelmracwqwnpsdrpsfaeihqafetmfqessisdevekelgkr

Sequence, based on observed residues (ATOM records):

>d3ik3a1 d.144.1.7 (A:229-513) Abelsone tyrosine kinase (abl) {Mouse (Mus musculus) [TaxId: 10090]}
spnydkwemertditmkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaa
vmkeikhpnlvqllgvctreppfyiiiefmtygnlldylrecnrqevsavvllymatqis
sameylekknfihrdlaarnclvgenhlvkvadfglstytahagakfpikwtapeslayn
kfsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpekvyelmra
cwqwnpsdrpsfaeihqafetmfqessisdevekelgkr

Timeline for d3ik3a1:

• d3ik3a1 first appeared in SCOPe 2.01, called d3ik3a_
  
• d3ik3a1 appears in SCOPe 2.07