SCOPe 2.04: Domain d3igba_: 3igb A:

Lineage for d3igba_ (3igb A:)

1. Root: SCOPe 2.04

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein beta-secretase (memapsin) [50671] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50672] (242 PDB entries)
   Uniprot P56817 58-446 ! Uniprot P56817 60-447

8. Domain d3igba_: 3igb A: [178305]
   automated match to d1fkna_
   complexed with 454

Details for d3igba_

PDB Entry: 3igb, 2.24 Å

PDB Description: Bace-1 with Compound 3

PDB Compounds: (A:) Beta-secretase 1

SCOPe Domain Sequences for d3igba_:

Sequence, based on SEQRES records:

>d3igba_ b.50.1.2 (A:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
sfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqls
styrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnweg
ilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmiig
gidhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlp
kkvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfr
itilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavs
achvhdefrtaavegpfvtldmedcgyn

Sequence, based on observed residues (ATOM records):

>d3igba_ b.50.1.2 (A:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
sfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqls
styrdlrkgvyvpykwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwegilg
layaeiarpddslepffdslvkqthvpnlfslqlcgagevlasvggsmiiggidhslytg
slwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaavk
sikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfritilpqqyl
rpvdcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsachvhdefrtaavegpf
vtledcgyn

Timeline for d3igba_:

• d3igba_ first appeared in SCOPe 2.01
  
• d3igba_ appears in SCOPe 2.03
  
• d3igba_ appears in SCOPe 2.05
  
• d3igba_ appears in the current release, SCOPe 2.08