SCOPe 2.07: Domain d3iejb1: 3iej B:1-217

Lineage for d3iejb1 (3iej B:1-217)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.3: Cysteine proteinases [54000] (1 superfamily)
   consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn

4. Superfamily d.3.1: Cysteine proteinases [54001] (24 families)
   the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet

5. Family d.3.1.1: Papain-like [54002] (26 protein domains)

6. Protein (Pro)cathepsin S [82566] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [82567] (28 PDB entries)

8. Domain d3iejb1: 3iej B:1-217 [178272]
   Other proteins in same PDB: d3ieja2, d3ieja3, d3iejb2, d3iejb3
   automated match to d1gloa_
   complexed with 599

Details for d3iejb1

PDB Entry: 3iej, 2.18 Å

PDB Description: Pyrazole-based Cathepsin S Inhibitors with Arylalkynes as P1 Binding Elements

PDB Compounds: (B:) cathepsin S

SCOPe Domain Sequences for d3iejb1:

Sequence; same for both SEQRES and ATOM records:

>d3iejb1 d.3.1.1 (B:1-217) (Pro)cathepsin S {Human (Homo sapiens) [TaxId: 9606]}
lpdsvdwrekgcvtevkyqgscgaswafsavgaleaqlklktgklvslsaqnlvdcstek
ygnkgcnggfmttafqyiidnkgidsdasypykamdqkcqydskyraatcskytelpygr
edvlkeavankgpvsvgvdarhpsfflyrsgvyyepsctqnvnhgvlvvgygdlngkeyw
lvknswghnfgeegyirmarnkgnhcgiasfpsypei

Timeline for d3iejb1:

• d3iejb1 first appeared in SCOPe 2.01, called d3iejb_
  
• d3iejb1 appears in SCOPe 2.06