SCOPe 2.05: Domain d3ia4c_: 3ia4 C:

Lineage for d3ia4c_ (3ia4 C:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

4. Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families)

5. Family c.71.1.0: automated matches [191485] (1 protein)
   not a true family

6. Protein automated matches [190777] (19 species)
   not a true protein

7. Species Moritella profunda [TaxId:111291] [189013] (3 PDB entries)

8. Domain d3ia4c_: 3ia4 C: [178198]
   automated match to d1dhja_
   complexed with mtx, ndp

Details for d3ia4c_

PDB Entry: 3ia4, 1.7 Å

PDB Description: Moritella profunda dihydrofolate reductase (DHFR) in complex with NADPH and methotrexate (MTX)

PDB Compounds: (C:) dihydrofolate reductase

SCOPe Domain Sequences for d3ia4c_:

Sequence, based on SEQRES records:

>d3ia4c_ c.71.1.0 (C:) automated matches {Moritella profunda [TaxId: 111291]}
mivsmiaalannrvigldnkmpwhlpaelqlfkratlgkpivmgrntfesigrplpgrln
ivlsrqtdyqpegvtvvatledavvaagdveelmiiggatiynqclaaadrlylthielt
tegdtwfpdyeqynwqeiehesyaaddknphnyrfsllerv

Sequence, based on observed residues (ATOM records):

>d3ia4c_ c.71.1.0 (C:) automated matches {Moritella profunda [TaxId: 111291]}
mivsmiaalannrvigldnkmpwhlpaelqlfkratlgkpivmgrntfesigrplpgrln
ivlsrqdyqpegvtvvatledavvaagdveelmiiggatiynqclaaadrlylthieltt
egdtwfpdyeqynwqeiehesyaaddknphnyrfsllerv

Timeline for d3ia4c_:

• d3ia4c_ first appeared in SCOPe 2.01
  
• d3ia4c_ appears in SCOPe 2.04
  
• d3ia4c_ appears in SCOPe 2.06
  
• d3ia4c_ appears in the current release, SCOPe 2.08