Lineage for d3h6kb_ (3h6k B:)

  1. Root: SCOPe 2.01
  2. 968085Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 975118Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 975119Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 975436Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
  6. 975463Protein 11-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species)
  7. 975479Species Human (Homo sapiens) [TaxId:9606] [117424] (19 PDB entries)
    Uniprot P28845
  8. 975501Domain d3h6kb_: 3h6k B: [177285]
    automated match to d1xu9a_
    complexed with 33t, nap

Details for d3h6kb_

PDB Entry: 3h6k (more details), 2.19 Å

PDB Description: crystal structure of human 11-beta-hydroxysteroid-dehydrogenase bound to an ortho-chlro-sulfonyl-piperazine inhibitor
PDB Compounds: (B:) Corticosteroid 11-beta-dehydrogenase isozyme 1

SCOPe Domain Sequences for d3h6kb_:

Sequence; same for both SEQRES and ATOM records: (download)

>d3h6kb_ c.2.1.2 (B:) 11-beta-hydroxysteroid dehydrogenase 1 {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d3h6kb_:

Click to download the PDB-style file with coordinates for d3h6kb_.
(The format of our PDB-style files is described here.)

Timeline for d3h6kb_: