SCOPe 2.06: Domain d3h4ga_: 3h4g A:

Lineage for d3h4ga_ (3h4g A:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.7: NAD(P)-linked oxidoreductase [51430] (2 families)

5. Family c.1.7.1: Aldo-keto reductases (NADP) [51431] (16 proteins)
   Common fold covers whole protein structure

6. Protein Aldose reductase (aldehyde reductase) [51436] (2 species)

7. Species Pig (Sus scrofa) [TaxId:9823] [51438] (12 PDB entries)

8. Domain d3h4ga_: 3h4g A: [177175]
   automated match to d1ae4a_
   protein/RNA complex; complexed with fid, nap, so4

Details for d3h4ga_

PDB Entry: 3h4g, 1.85 Å

PDB Description: Structure of aldehyde reductase holoenzyme in complex with potent aldose reductase inhibitor Fidarestat: Implications for inhibitor binding and selectivity

PDB Compounds: (A:) Alcohol dehydrogenase [NADP+]

SCOPe Domain Sequences for d3h4ga_:

Sequence, based on SEQRES records:

>d3h4ga_ c.1.7.1 (A:) Aldose reductase (aldehyde reductase) {Pig (Sus scrofa) [TaxId: 9823]}
maascvllhtgqkmpliglgtwksepgqvkaaikyaltvgyrhidcaaiygneleigeal
qetvgpgkavpreelfvtsklwntkhhpedvepalrktladlqleyldlylmhwpyafer
gdnpfpknadgtirydathykdtwkalealvakglvralglsnfssrqiddvlsvasvrp
avlqvechpylaqneliahcqarglevtaysplgssdrawrdpnepvlleepvvqalaek
ynrspaqillrwqvqrkvicipksvtpsrilqniqvfdftfspeemkqldalnknlrfiv
pmltvdgkrvprdaghplypfndp

Sequence, based on observed residues (ATOM records):

>d3h4ga_ c.1.7.1 (A:) Aldose reductase (aldehyde reductase) {Pig (Sus scrofa) [TaxId: 9823]}
maascvllhtgqkmpliglgtwksepgqvkaaikyaltvgyrhidcaaiygneleigeal
qetvgpgkavpreelfvtsklwntkhhpedvepalrktladlqleyldlylmhwpyafer
gdnpfpknadgtirydathykdtwkalealvakglvralglsnfssrqiddvlsvasvrp
avlqvechpylaqneliahcqarglevtaysplgssdrawrdpnepvlleepvvqalaek
ynrspaqillrwqvqrkvicipksvtpsrilqniqvfdftfspeemkqldalnknlrfiv
pmltrvprdaghplypfndp

Timeline for d3h4ga_:

• d3h4ga_ first appeared in SCOPe 2.01
  
• d3h4ga_ appears in SCOPe 2.05
  
• d3h4ga_ appears in SCOPe 2.07
  
• d3h4ga_ appears in the current release, SCOPe 2.08