SCOPe 2.05: Domain d3h0ea_: 3h0e A:

Lineage for d3h0ea_ (3h0e A:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.17: Caspase-like [52128] (1 superfamily)
   3 layers, a/b/a; core: mixed beta-sheet of 6 strands, order 213456, strand 6 is antiparallel to the rest

4. Superfamily c.17.1: Caspase-like [52129] (3 families)
   mature protein may be composed of two chains folded in a single domain

5. Family c.17.1.1: Caspase catalytic domain [52130] (8 proteins)

6. Protein Apopain (caspase-3, cpp32) [52131] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [52132] (28 PDB entries)

8. Domain d3h0ea_: 3h0e A: [177130]
   automated match to d1nmqa_
   complexed with h0e

Details for d3h0ea_

PDB Entry: 3h0e, 2 Å

PDB Description: 3,4-Dihydropyrimido(1,2-a)indol-10(2H)-ones as Potent Non-Peptidic Inhibitors of Caspase-3

PDB Compounds: (A:) Caspase-3

SCOPe Domain Sequences for d3h0ea_:

Sequence, based on SEQRES records:

>d3h0ea_ c.17.1.1 (A:) Apopain (caspase-3, cpp32) {Human (Homo sapiens) [TaxId: 9606]}
dnsykmdypemglciiinnknfhkstgmtsrsgtdvdaanlretfrnlkyevrnkndltr
eeivelmrdvskedhskrssfvcvllshgeegiifgtngpvdlkkitnffrgdrcrsltg
kpklfiiqacrgteldcgietdsgvdddmachkipveadflyaystapgyyswrnskdgs
wfiqslcamlkqyadklefmhiltrvnrkvatefesfsfdatfhakkqipcivsmltkel
yfy

Sequence, based on observed residues (ATOM records):

>d3h0ea_ c.17.1.1 (A:) Apopain (caspase-3, cpp32) {Human (Homo sapiens) [TaxId: 9606]}
dnsykmdypemglciiinnknfhkstgmtsrsgtdvdaanlretfrnlkyevrnkndltr
eeivelmrdvskedhskrssfvcvllshgeegiifgtngpvdlkkitnffrgdrcrsltg
kpklfiiqacrgteldcgieddmachkipveadflyaystapgyyswrnskdgswfiqsl
camlkqyadklefmhiltrvnrkvatefesfsfdatfhakkqipcivsmltkelyfy

Timeline for d3h0ea_:

• d3h0ea_ first appeared in SCOPe 2.01
  
• d3h0ea_ appears in SCOPe 2.04
  
• d3h0ea_ appears in SCOPe 2.06
  
• d3h0ea_ appears in the current release, SCOPe 2.08