SCOPe 2.05: Domain d3h0aa_: 3h0a A:

Lineage for d3h0aa_ (3h0a A:)

1. Root: SCOPe 2.05

2. Class a: All alpha proteins [46456] (286 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Retinoid-X receptor alpha (RXR-alpha) [48510] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48511] (34 PDB entries)
   Uniprot P19793 227-458

8. Domain d3h0aa_: 3h0a A: [177125]
   Other proteins in same PDB: d3h0ad_
   automated match to d1fbya_
   protein/DNA complex; complexed with 9ra, d30

Details for d3h0aa_

PDB Entry: 3h0a, 2.1 Å

PDB Description: Crystal Structure of Peroxisome Proliferator-Activated Receptor Gamma (PPARg) and Retinoic Acid Receptor Alpha (RXRa) in Complex with 9-cis Retinoic Acid, Co-activator Peptide, and a Partial Agonist

PDB Compounds: (A:) Retinoic acid receptor RXR-alpha

SCOPe Domain Sequences for d3h0aa_:

Sequence, based on SEQRES records:

>d3h0aa_ a.123.1.1 (A:) Retinoid-X receptor alpha (RXR-alpha) {Human (Homo sapiens) [TaxId: 9606]}
edmpverileaelavepktetyveanmglnpsspndpvtnicqaadkqlftlvewakrip
hfselplddqvillragwnelliasfshrsiavkdgillatglhvhrnsahsagvgaifd
rvltelvskmrdmqmdktelgclraivlfnpdskglsnpaevealrekvyasleayckhk
ypeqpgrfaklllrlpalrsiglkclehlfffkligdtpidtflmeml

Sequence, based on observed residues (ATOM records):

>d3h0aa_ a.123.1.1 (A:) Retinoid-X receptor alpha (RXR-alpha) {Human (Homo sapiens) [TaxId: 9606]}
edmpverileaelavendpvtnicqaadkqlftlvewakriphfselplddqvillragw
nelliasfshrsiavkdgillatglhvhrnsahsagvgaifdrvltelvskmrdmqmdkt
elgclraivlfnpdskglsnpaevealrekvyasleayckhkypeqpgrfaklllrlpal
rsiglkclehlfffkligdtpidtflmeml

Timeline for d3h0aa_:

• d3h0aa_ first appeared in SCOPe 2.01
  
• d3h0aa_ appears in SCOPe 2.04
  
• d3h0aa_ appears in SCOPe 2.06
  
• d3h0aa_ appears in the current release, SCOPe 2.08