Lineage for d3gxla_ (3gxl A:)

  1. Root: SCOPe 2.06
  2. 2170735Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2218047Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2218048Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2218179Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 2220743Protein Type I TGF-beta receptor R4 [56144] (1 species)
    TKL group; STKR subfamily; serine/threonine kinase; possible evolutionary link to tyrosine kinases
  7. 2220744Species Human (Homo sapiens) [TaxId:9606] [56145] (25 PDB entries)
    Uniprot P36897 200-500 ! Uniprot P36897 201-503
  8. 2220755Domain d3gxla_: 3gxl A: [177074]
    automated match to d1vjya_
    complexed with qig

Details for d3gxla_

PDB Entry: 3gxl (more details), 1.8 Å

PDB Description: alk-5 kinase complex with gw857175
PDB Compounds: (A:) TGF-beta receptor type-1

SCOPe Domain Sequences for d3gxla_:

Sequence, based on SEQRES records: (download)

>d3gxla_ d.144.1.7 (A:) Type I TGF-beta receptor R4 {Human (Homo sapiens) [TaxId: 9606]}
iartivlqesigkgrfgevwrgkwrgeevavkifssreerswfreaeiyqtvmlrhenil
gfiaadnkdngtwtqlwlvsdyhehgslfdylnrytvtvegmiklalstasglahlhmei
vgtqgkpaiahrdlksknilvkkngtcciadlglavrhdsatdtidiapnhrvgtkryma
pevlddsinmkhfesfkradiyamglvfweiarrcsiggihedyqlpyydlvpsdpsvee
mrkvvceqklrpnipnrwqscealrvmakimrecwyangaarltalrikktlsqlsqq

Sequence, based on observed residues (ATOM records): (download)

>d3gxla_ d.144.1.7 (A:) Type I TGF-beta receptor R4 {Human (Homo sapiens) [TaxId: 9606]}
iartivlqesigkgrfgevwrgkwevavkifssreerswfreaeiyqtvmlrhenilgfi
aadnkdngtwtqlwlvsdyhehgslfdylnrytvtvegmiklalstasglahlhmeivgt
qgkpaiahrdlksknilvkkngtcciadlglavrhdsatdtidrvgtkrymapevlddsi
nmkhfesfkradiyamglvfweiarrcsihedyqlpyydlvpsdpsveemrkvvceqklr
pnipnrscealrvmakimrecwyangaarltalrikktlsqlsqq

SCOPe Domain Coordinates for d3gxla_:

Click to download the PDB-style file with coordinates for d3gxla_.
(The format of our PDB-style files is described here.)

Timeline for d3gxla_: