SCOPe 2.08: Domain d3gnvb_: 3gnv B:

Lineage for d3gnvb_ (3gnv B:)

1. Root: SCOPe 2.08

2. Class e: Multi-domain proteins (alpha and beta) [56572] (74 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (9 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

6. Protein Viral RNA polymerase [56695] (17 species)

7. Species Hepatitis C virus [TaxId:420174] [188905] (22 PDB entries)

8. Domain d3gnvb_: 3gnv B: [176784]
   automated match to d1nb4a_
   protein/RNA complex; complexed with gol, xnz

Details for d3gnvb_

PDB Entry: 3gnv, 2.75 Å

PDB Description: HCV NS5B polymerase in complex with 1,5 benzodiazepine inhibitor 1b

PDB Compounds: (B:) RNA-directed RNA polymerase

SCOPe Domain Sequences for d3gnvb_:

Sequence, based on SEQRES records:

>d3gnvb_ e.8.1.4 (B:) Viral RNA polymerase {Hepatitis C virus [TaxId: 420174]}
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiy
qccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkat
aacraaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsyspg
einrvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpip
aasqldlsgwfvagysggdiyhs

Sequence, based on observed residues (ATOM records):

>d3gnvb_ e.8.1.4 (B:) Viral RNA polymerase {Hepatitis C virus [TaxId: 420174]}
smsytwtgalitpcaaeesklpllrhhnmvyattsrsaslrqkkvtfdrlqvlddhyrdv
lkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhirsvwedll
edtetpidttimaksevfcvqpgrkparlivfpdlgvrvcekmalydvvstlpqavmgss
ygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiyqccdlapear
qairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkataacraaklqd
ctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydlelitscssnv
svahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlwarmilmthff
sillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsyspgeinrvasclr
klgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpipaasqldlsgw
fvagysggdiyhs

Timeline for d3gnvb_:

• d3gnvb_ first appeared in SCOPe 2.01
  
• d3gnvb_ appears in SCOPe 2.07