SCOPe 2.06: Domain d3ghua_: 3ghu A:

Lineage for d3ghua_ (3ghu A:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.7: NAD(P)-linked oxidoreductase [51430] (2 families)

5. Family c.1.7.1: Aldo-keto reductases (NADP) [51431] (16 proteins)
   Common fold covers whole protein structure

6. Protein Aldose reductase (aldehyde reductase) [51436] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [51437] (135 PDB entries)
   Uniprot P15121

8. Domain d3ghua_: 3ghu A: [176653]
   automated match to d1el3a_
   complexed with cit, ldt, ndp

Details for d3ghua_

PDB Entry: 3ghu, 1.2 Å

PDB Description: Human aldose reductase in complex with NADP+ and the inhibitor IDD594. Investigation of global effects of radiation damage on protein structure. Forth stage of radiation damage.

PDB Compounds: (A:) aldose reductase

SCOPe Domain Sequences for d3ghua_:

Sequence; same for both SEQRES and ATOM records:

>d3ghua_ c.1.7.1 (A:) Aldose reductase (aldehyde reductase) {Human (Homo sapiens) [TaxId: 9606]}
masrillnngakmpilglgtwksppgqvteavkvaidvgyrhidcahvyqnenevgvaiq
eklreqvvkreelfivsklwctyhekglvkgacqktlsdlkldyldlylihwptgfkpgk
effpldesgnvvpsdtnildtwaameelvdeglvkaigisnfnhlqvemilnkpglkykp
avnqiechpyltqekliqycqskgivvtaysplgspdrpwakpedpslledprikaiaak
hnkttaqvlirfpmqrnlvvipksvtperiaenfkvfdfelssqdmttllsynrnwrvca
llsctshkdypfheef

Timeline for d3ghua_:

• d3ghua_ first appeared in SCOPe 2.01
  
• d3ghua_ appears in SCOPe 2.05
  
• d3ghua_ appears in SCOPe 2.07
  
• d3ghua_ appears in the current release, SCOPe 2.08