SCOPe 2.08: Domain d3g8ia_: 3g8i A:

Lineage for d3g8ia_ (3g8i A:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Peroxisome proliferator activated receptor alpha, PPAR-alpha [69109] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [69110] (30 PDB entries)

8. Domain d3g8ia_: 3g8i A: [176419]
   automated match to d1i7ga_
   protein/DNA complex; complexed with ro7

Details for d3g8ia_

PDB Entry: 3g8i, 2.2 Å

PDB Description: Aleglitazar, a new, potent, and balanced PPAR alpha/gamma agonist for the treatment of type II diabetes

PDB Compounds: (A:) Peroxisome proliferator-activated receptor alpha

SCOPe Domain Sequences for d3g8ia_:

Sequence, based on SEQRES records:

>d3g8ia_ a.123.1.1 (A:) Peroxisome proliferator activated receptor alpha, PPAR-alpha {Human (Homo sapiens) [TaxId: 9606]}
dlkslakriyeaylknfnmnkvkarvilsgkasnnppfvihdmetlcmaektlvaklvan
giqnkeaevrifhccqctsvetvteltefakaipgfanldlndqvtllkygvyeaifaml
ssvmnkdgmlvaygngfitreflkslrkpfcdimepkfdfamkfnalelddsdislfvaa
iiccgdrpgllnvghiekmqegivhvlrlhlqsnhpddiflfpkllqkmadlrqlvteha
qlvqiikktesdaalhpllqeiyrdmy

Sequence, based on observed residues (ATOM records):

>d3g8ia_ a.123.1.1 (A:) Peroxisome proliferator activated receptor alpha, PPAR-alpha {Human (Homo sapiens) [TaxId: 9606]}
dlkslakriyeaylknfnmnkvkarvilsppfvihdmetlcmaektlvaklkeaevrifh
ccqctsvetvteltefakaipgfanldlndqvtllkygvyeaifamlssvmnkdgmlvay
gngfitreflkslrkpfcdimepkfdfamkfnalelddsdislfvaaiiccgdrpgllnv
ghiekmqegivhvlrlhlqsnhpddiflfpkllqkmadlrqlvtehaqlvqiikktesda
alhpllqeiyrdmy

Timeline for d3g8ia_:

• d3g8ia_ first appeared in SCOPe 2.01
  
• d3g8ia_ appears in SCOPe 2.07