SCOPe 2.07: Domain d3g70b1: 3g70 B:1-340

Lineage for d3g70b1 (3g70 B:1-340)

1. Root: SCOPe 2.07

2. Class b: All beta proteins [48724] (178 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein Chymosin (synonym: renin) [50667] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50669] (76 PDB entries)

8. Domain d3g70b1: 3g70 B:1-340 [176403]
   Other proteins in same PDB: d3g70a2, d3g70b2
   automated match to d1bila_
   complexed with a5t, dms, nag, ndg

Details for d3g70b1

PDB Entry: 3g70, 2 Å

PDB Description: design and preparation of potent, non-peptidic, bioavailable renin inhibitors

PDB Compounds: (B:) renin

SCOPe Domain Sequences for d3g70b1:

Sequence, based on SEQRES records:

>d3g70b1 b.50.1.2 (B:1-340) Chymosin (synonym: renin) {Human (Homo sapiens) [TaxId: 9606]}
ltlgnttssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvy
hklfdasdsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfm
laefdgvvgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdsensqslggqivlgg
sdpqhyegnfhyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssie
klmealgakkrlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlai
hamdippptgptwalgatfirkfytefdrrnnrigfalar

Sequence, based on observed residues (ATOM records):

>d3g70b1 b.50.1.2 (B:1-340) Chymosin (synonym: renin) {Human (Homo sapiens) [TaxId: 9606]}
ltlgnttssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvy
hklfdasdsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfm
laefdgvvgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdsslggqivlggsdpq
hyegnfhyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssieklme
algakkrlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlaihamd
ippptgptwalgatfirkfytefdrrnnrigfalar

Timeline for d3g70b1:

• d3g70b1 first appeared in SCOPe 2.01, called d3g70b_
  
• d3g70b1 appears in SCOPe 2.06
  
• d3g70b1 appears in the current release, SCOPe 2.08