SCOPe 2.06: Domain d3g70a1: 3g70 A:4-340

Lineage for d3g70a1 (3g70 A:4-340)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein Chymosin (synonym: renin) [50667] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50669] (76 PDB entries)

8. Domain d3g70a1: 3g70 A:4-340 [176402]
   Other proteins in same PDB: d3g70a2, d3g70b2
   automated match to d1bila_
   complexed with a5t, dms, nag, ndg

Details for d3g70a1

PDB Entry: 3g70, 2 Å

PDB Description: design and preparation of potent, non-peptidic, bioavailable renin inhibitors

PDB Compounds: (A:) renin

SCOPe Domain Sequences for d3g70a1:

Sequence, based on SEQRES records:

>d3g70a1 b.50.1.2 (A:4-340) Chymosin (synonym: renin) {Human (Homo sapiens) [TaxId: 9606]}
gnttssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvyhkl
fdasdsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfmlae
fdgvvgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdsensqslggqivlggsdp
qhyegnfhyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssieklm
ealgakkrlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlaiham
dippptgptwalgatfirkfytefdrrnnrigfalar

Sequence, based on observed residues (ATOM records):

>d3g70a1 b.50.1.2 (A:4-340) Chymosin (synonym: renin) {Human (Homo sapiens) [TaxId: 9606]}
gnttssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvyhkl
fdasdsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfmlae
fdgvvgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdsslggqivlggsdpqhye
gnfhyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssieklmealg
akkrlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlaihamdipp
ptgptwalgatfirkfytefdrrnnrigfalar

Timeline for d3g70a1:

• d3g70a1 first appeared in SCOPe 2.01, called d3g70a_
  
• d3g70a1 was called d3g70a_ in SCOPe 2.05
  
• d3g70a1 appears in SCOPe 2.07
  
• d3g70a1 appears in the current release, SCOPe 2.08