SCOPe 2.05: Domain d3g6za_: 3g6z A:

Lineage for d3g6za_ (3g6z A:)

1. Root: SCOPe 2.05

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein Chymosin (synonym: renin) [50667] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50669] (66 PDB entries)

8. Domain d3g6za_: 3g6z A: [176400]
   automated match to d1bila_
   complexed with a7t, nag, ndg

Details for d3g6za_

PDB Entry: 3g6z, 2 Å

PDB Description: design and preparation of potent, non-peptidic, bioavailable renin inhibitors

PDB Compounds: (A:) renin

SCOPe Domain Sequences for d3g6za_:

Sequence, based on SEQRES records:

>d3g6za_ b.50.1.2 (A:) Chymosin (synonym: renin) {Human (Homo sapiens) [TaxId: 9606]}
ltlgnttssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvy
hklfdasdsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfm
laefdgvvgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdsensqslggqivlgg
sdpqhyegnfhyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssie
klmealgakkrlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlai
hamdippptgptwalgatfirkfytefdrrnnrigfalarh

Sequence, based on observed residues (ATOM records):

>d3g6za_ b.50.1.2 (A:) Chymosin (synonym: renin) {Human (Homo sapiens) [TaxId: 9606]}
ltlgnttssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvy
hklfdasdsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfm
laefdgvvgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdsslggqivlggsdpq
hyegnfhyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssieklme
algakkrlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlaihamd
ippptgptwalgatfirkfytefdrrnnrigfalarh

Timeline for d3g6za_:

• d3g6za_ first appeared in SCOPe 2.01
  
• d3g6za_ appears in SCOPe 2.04
  
• d3g6za_ is called d3g6za1 in SCOPe 2.06
  
• d3g6za_ appears in the current release, SCOPe 2.08, called d3g6za1