SCOPe 2.08: Domain d3fuga_: 3fug A:

Lineage for d3fuga_ (3fug A:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Retinoid-X receptor alpha (RXR-alpha) [48510] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48511] (38 PDB entries)
   Uniprot P19793 227-458

8. Domain d3fuga_: 3fug A: [176063]
   automated match to d1lbda_
   protein/DNA complex; complexed with 2e3

Details for d3fuga_

PDB Entry: 3fug, 2 Å

PDB Description: Crystal Structure of the Retinoid X Receptor Ligand Binding Domain Bound to the Synthetic Agonist 3-[4-Hydroxy-3-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-phenyl]acrylic Acid

PDB Compounds: (A:) Retinoic acid receptor RXR-alpha

SCOPe Domain Sequences for d3fuga_:

Sequence, based on SEQRES records:

>d3fuga_ a.123.1.1 (A:) Retinoid-X receptor alpha (RXR-alpha) {Human (Homo sapiens) [TaxId: 9606]}
dmpverileaelavepktetyveanmglnpsspndpvtnicqaadkqlftlvewakriph
fselplddqvillragwnelliasfshrsiavkdgillatglhvhrnsahsagvgaifdr
vltelvskmrdmqmdktelgclraivlfnpdskglsnpaevealrekvyasleayckhky
peqpgrfaklllrlpalrsiglkclehlfffkligdtpidtflmemleap

Sequence, based on observed residues (ATOM records):

>d3fuga_ a.123.1.1 (A:) Retinoid-X receptor alpha (RXR-alpha) {Human (Homo sapiens) [TaxId: 9606]}
dmpverileaelavedpvtnicqaadkqlftlvewakriphfselplddqvillragwne
lliasfshrsiavkdgillatglhvhrnsahsagvgaifdrvltelvskmrdmqmdktel
gclraivlfnpdskglsnpaevealrekvyasleayckhkypeqpgrfaklllrlpalrs
iglkclehlfffkligdtpidtflmemleap

Timeline for d3fuga_:

• d3fuga_ first appeared in SCOPe 2.01
  
• d3fuga_ appears in SCOPe 2.07