SCOPe 2.02: Domain d3fmka_: 3fmk A:

Lineage for d3fmka_ (3fmk A:)

1. Root: SCOPe 2.02

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein MAP kinase p38 [56129] (2 species)
   CMGC group; ERK/MAPK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56130] (124 PDB entries)

8. Domain d3fmka_: 3fmk A: [175905]
   automated match to d1a9ua_
   complexed with fmk

Details for d3fmka_

PDB Entry: 3fmk, 1.7 Å

PDB Description: p38 kinase crystal structure in complex with 6-(2,4-difluoro-phenoxy)- 8-methyl-2-((s)-1-methyl-2-tetrazol-2-yl-ethylamino)-8h-pyrido[2,3- d]pyrimidin-7-one

PDB Compounds: (A:) Mitogen-activated protein kinase 14

SCOPe Domain Sequences for d3fmka_:

Sequence, based on SEQRES records:

>d3fmka_ d.144.1.7 (A:) MAP kinase p38 {Human (Homo sapiens) [TaxId: 9606]}
erptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktglrvavkklsrpfqsii
hakrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqklt
ddhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglarhtddemtgyv
atrwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpg
aellkkissesarnyiqsltqmpkmnfanvfiganplavdllekmlvldsdkritaaqal
ahayfaqyhdpddepvadpydqsfesrdllidewksltydevisfvppp

Sequence, based on observed residues (ATOM records):

>d3fmka_ d.144.1.7 (A:) MAP kinase p38 {Human (Homo sapiens) [TaxId: 9606]}
erptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktglrvavkklsrpfqsii
hakrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqklt
ddhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfgltddemtgyvatr
wyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpgael
lkkissesarnyiqsltqmpkmnfanvfiganplavdllekmlvldsdkritaaqalaha
yfaqyhdpddepvadpydqsfesrdllidewksltydevisfvppp

Timeline for d3fmka_:

• d3fmka_ first appeared in SCOPe 2.01
  
• d3fmka_ appears in SCOPe 2.03
  
• d3fmka_ appears in the current release, SCOPe 2.08