SCOPe 2.07: Domain d3fc6a_: 3fc6 A:

Lineage for d3fc6a_ (3fc6 A:)

1. Root: SCOPe 2.07

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Retinoid-X receptor alpha (RXR-alpha) [48510] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48511] (39 PDB entries)
   Uniprot P19793 227-458

8. Domain d3fc6a_: 3fc6 A: [175671]
   Other proteins in same PDB: d3fc6b_, d3fc6d_
   automated match to d1lbda_
   complexed with lx2, rea

Details for d3fc6a_

PDB Entry: 3fc6, 2.06 Å

PDB Description: hRXRalpha & mLXRalpha with an indole Pharmacophore, SB786875

PDB Compounds: (A:) Retinoic acid receptor RXR-alpha

SCOPe Domain Sequences for d3fc6a_:

Sequence, based on SEQRES records:

>d3fc6a_ a.123.1.1 (A:) Retinoid-X receptor alpha (RXR-alpha) {Human (Homo sapiens) [TaxId: 9606]}
sanedmpverileaelavepktetyveanmglnpsspndpvtnicqaadkqlftlvewak
riphfselplddqvillragwnelliasfshrsiavkdgillatglhvhrnsahsagvga
ifdrvltelvskmrdmqmdktelgclraivlfnpdskglsnpaevealrekvyasleayc
khkypeqpgrfaklllrlpalrsiglkclehlfffkligdtpidtflmemlea

Sequence, based on observed residues (ATOM records):

>d3fc6a_ a.123.1.1 (A:) Retinoid-X receptor alpha (RXR-alpha) {Human (Homo sapiens) [TaxId: 9606]}
sanedmpverileaelavdpvtnicqaadkqlftlvewakriphfselplddqvillrag
wnelliasfshrsiavkdgillatglhvhrnsahsagvgaifdrvltelvskmrdmqmdk
telgclraivlfnpdskglsnpaevealrekvyasleayckhkypeqpgrfaklllrlpa
lrsiglkclehlfffkldtflmemlea

Timeline for d3fc6a_:

• d3fc6a_ first appeared in SCOPe 2.01
  
• d3fc6a_ appears in SCOPe 2.06
  
• d3fc6a_ appears in the current release, SCOPe 2.08