SCOPe 2.08: Domain d3f82a_: 3f82 A:

Lineage for d3f82a_ (3f82 A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Hepatocyte growth factor receptor, c-MET [103300] (1 species)
   PTK group; HGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [103301] (67 PDB entries)

8. Domain d3f82a_: 3f82 A: [175561]
   automated match to d1r0pa_
   complexed with 353

Details for d3f82a_

PDB Entry: 3f82, 2.5 Å

PDB Description: crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-met in complex with n-(4-(2-amino-3- chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2- oxo-1,2-dihydropyridine-3-carboxamide

PDB Compounds: (A:) Hepatocyte growth factor receptor

SCOPe Domain Sequences for d3f82a_:

Sequence, based on SEQRES records:

>d3f82a_ d.144.1.7 (A:) Hepatocyte growth factor receptor, c-MET {Human (Homo sapiens) [TaxId: 9606]}
lsalnpelvqavqhvvigpsslivhfnevigrghfgcvyhgtlldndgkkihcavkslnr
itdigevsqfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrnfirneth
nptvkdligfglqvakgmkflaskkfvhrdlaarncmldekftvkvadfglardmydkef
dsvhnktgaklpvkwmaleslqtqkfttksdvwsfgvllwelmtrgappypdvntfditv
yllqgrrllqpeycpdplyevmlkcwhpkaemrpsfselvsrisaifstfigehyvhvna
tyvnvk

Sequence, based on observed residues (ATOM records):

>d3f82a_ d.144.1.7 (A:) Hepatocyte growth factor receptor, c-MET {Human (Homo sapiens) [TaxId: 9606]}
lsalnpelvqavqhvvigpsslivhfnevigrghfgcvyhgtllkihcavkslnrgevsq
fltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrnfirnethnptvkdlig
fglqvakgmkflaskkfvhrdlaarncmldekftvkvadfgklpvkwmaleslqtqkftt
ksdvwsfgvllwelmtrgappypdvntfditvyllqgrrllqpeycpdplyevmlkcwhp
kaemrpsfselvsrisaifstfigehyvhvnatyvnvk

Timeline for d3f82a_:

• d3f82a_ first appeared in SCOPe 2.01
  
• d3f82a_ appears in SCOPe 2.07