SCOPe 2.06: Domain d3f7zb1: 3f7z B:35-383

Lineage for d3f7zb1 (3f7z B:35-383)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Glycogen synthase kinase-3 beta (Gsk3b) [69823] (1 species)
   CMGC group; GSK3 subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [69824] (43 PDB entries)
   Uniprot P49841 35-383 ! Uniprot P49841 35-384

8. Domain d3f7zb1: 3f7z B:35-383 [175556]
   Other proteins in same PDB: d3f7za2, d3f7zb2
   automated match to d1gngb_
   complexed with 34o

Details for d3f7zb1

PDB Entry: 3f7z, 2.4 Å

PDB Description: x-ray co-crystal structure of glycogen synthase kinase 3beta in complex with an inhibitor

PDB Compounds: (B:) Glycogen synthase kinase-3 beta

SCOPe Domain Sequences for d3f7zb1:

Sequence, based on SEQRES records:

>d3f7zb1 d.144.1.7 (B:35-383) Glycogen synthase kinase-3 beta (Gsk3b) {Human (Homo sapiens) [TaxId: 9606]}
skvttvvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkvlqdkrfk
nrelqimrkldhcnivrlryffyssgekkdevylnlvldyvpetvyrvarhysrakqtlp
viyvklymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnv
syicsryyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlg
tptreqiremnpnytefkfpqikahpwtkvfrprtppeaialcsrlleytptarltplea
cahsffdelrdpnvklpngrdtpalfnfttqelssnpplatilipphar

Sequence, based on observed residues (ATOM records):

>d3f7zb1 d.144.1.7 (B:35-383) Glycogen synthase kinase-3 beta (Gsk3b) {Human (Homo sapiens) [TaxId: 9606]}
skvttvvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkvlqdkrfk
nrelqimrkldhcnivrlryffyssvylnlvldyvpetvyrvarhysrakqtlpviyvkl
ymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnvsyicsr
yyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlgtptreq
iremnpnytpqikahpwtkvfrprtppeaialcsrlleytptarltpleacahsffdelr
dpnvklpngrdtpalfnfttqelssnpplatilipphar

Timeline for d3f7zb1:

• d3f7zb1 first appeared in SCOPe 2.01, called d3f7zb_
  
• d3f7zb1 was called d3f7zb_ in SCOPe 2.05
  
• d3f7zb1 appears in SCOPe 2.07
  
• d3f7zb1 appears in the current release, SCOPe 2.08