SCOPe 2.06: Domain d3f1qa_: 3f1q A:

Lineage for d3f1qa_ (3f1q A:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.4: FMN-linked oxidoreductases [51395] (2 families)

5. Family c.1.4.1: FMN-linked oxidoreductases [51396] (19 proteins)

6. Protein Dihydroorotate dehydrogenase [51397] (8 species)

7. Species Human (Homo sapiens) [TaxId:9606] [51400] (43 PDB entries)

8. Domain d3f1qa_: 3f1q A: [175415]
   automated match to d1d3ga_
   complexed with acy, bce, fmn, oro, so4

Details for d3f1qa_

PDB Entry: 3f1q, 2 Å

PDB Description: Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 1

PDB Compounds: (A:) dihydroorotate dehydrogenase

SCOPe Domain Sequences for d3f1qa_:

Sequence, based on SEQRES records:

>d3f1qa_ c.1.4.1 (A:) Dihydroorotate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
gderfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfrnpv
giaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnsh
glsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvn
vsspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvv
kelgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiig
vggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaiga
dhrr

Sequence, based on observed residues (ATOM records):

>d3f1qa_ c.1.4.1 (A:) Dihydroorotate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
gderfyaehlmptlqglldpesahrlavrftslgllpfqdsdmlevrvlghkfrnpvgia
agfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnshgls
vvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvnvss
pntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvvkel
gidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiigvgg
vssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaigadhr
r

Timeline for d3f1qa_:

• d3f1qa_ first appeared in SCOPe 2.01
  
• d3f1qa_ appears in SCOPe 2.05
  
• d3f1qa_ appears in SCOPe 2.07
  
• d3f1qa_ appears in the current release, SCOPe 2.08