SCOPe 2.03: Domain d3ewha_: 3ewh A:

Lineage for d3ewha_ (3ewh A:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Vascular endothelial growth factor receptor 2 (kdr) [56160] (1 species)
   PTK group; PDGFR/VEGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56161] (20 PDB entries)

8. Domain d3ewha_: 3ewh A: [175280]
   automated match to d1vr2a_
   complexed with edo, k11

Details for d3ewha_

PDB Entry: 3ewh, 1.6 Å

PDB Description: crystal structure of the vegfr2 kinase domain in complex with a pyridyl-pyrimidine benzimidazole inhibitor

PDB Compounds: (A:) Vascular endothelial growth factor receptor 2

SCOPe Domain Sequences for d3ewha_:

Sequence, based on SEQRES records:

>d3ewha_ d.144.1.7 (A:) Vascular endothelial growth factor receptor 2 (kdr) {Human (Homo sapiens) [TaxId: 9606]}
ehaerlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkega
thsehralmselkilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrne
fvpykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvki
cdfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgas
pypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnll
qanaqqdrhhhh

Sequence, based on observed residues (ATOM records):

>d3ewha_ d.144.1.7 (A:) Vascular endothelial growth factor receptor 2 (kdr) {Human (Homo sapiens) [TaxId: 9606]}
ehaerlpydaskwefprdrlklgkplgrgafgqvieadafgidtcrtvavkmlkegaths
ehralmselkilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrnefvp
ykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvkicdf
glardpdyvrlplkwmapetifdrvytiqsdvwsfgvllweifslgaspypgvkideefc
rrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnllqanaqqdrhhhh

Timeline for d3ewha_:

• d3ewha_ first appeared in SCOPe 2.01
  
• d3ewha_ appears in SCOPe 2.02
  
• d3ewha_ appears in SCOPe 2.04
  
• d3ewha_ appears in the current release, SCOPe 2.08, called d3ewha1