SCOPe 2.07: Domain d3eqra_: 3eqr A:

Lineage for d3eqra_ (3eqr A:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Activated CDC42 kinase 1, ACK1 [111200] (1 species)
   PTK group; Tck subfamily; non-membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [111201] (10 PDB entries)
   Uniprot Q07912 117-389

8. Domain d3eqra_: 3eqr A: [175162]
   automated match to d1u46b_
   complexed with cl, t74

Details for d3eqra_

PDB Entry: 3eqr, 2 Å

PDB Description: Crystal Structure of Ack1 with compound T74

PDB Compounds: (A:) Activated CDC42 kinase 1

SCOPe Domain Sequences for d3eqra_:

Sequence, based on SEQRES records:

>d3eqra_ d.144.1.7 (A:) Activated CDC42 kinase 1, ACK1 {Human (Homo sapiens) [TaxId: 9606]}
ltcligekdlrlleklgdgsfgvvrrgewdapsgktvsvavkclkpdvlsqpeamddfir
evnamhsldhrnlirlygvvltppmkmvtelaplgslldrlrkhqghfllgtlsryavqv
aegmgyleskrfihrdlaarnlllatrdlvkigdfglmralpqnddhyvmqehrkvpfaw
capeslktrtfshasdtwmfgvtlwemftygqepwiglngsqilhkidkegerlprpedc
pqdiynvmvqcwahkpedrptfvalrdflleaqptd

Sequence, based on observed residues (ATOM records):

>d3eqra_ d.144.1.7 (A:) Activated CDC42 kinase 1, ACK1 {Human (Homo sapiens) [TaxId: 9606]}
ltcligekdlrlleklgdgsfgvvrrgewdapsgktvsvavkclkpeamddfirevnamh
sldhrnlirlygvvltppmkmvtelaplgslldrlrkhqghfllgtlsryavqvaegmgy
leskrfihrdlaarnlllatrdlvkigdfglmralpqnddhyvmqehrkvpfawcapesl
ktrtfshasdtwmfgvtlwemftygqepwiglngsqilhkidkegerlprpedcpqdiyn
vmvqcwahkpedrptfvalrdflleaqptd

Timeline for d3eqra_:

• d3eqra_ first appeared in SCOPe 2.01
  
• d3eqra_ appears in SCOPe 2.06
  
• d3eqra_ appears in the current release, SCOPe 2.08