SCOPe 2.08: Domain d3emga_: 3emg A:

Lineage for d3emga_ (3emg A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Tyrosine-protein kinase SYK [118131] (1 species)
   PTK group; SYK/ZAP-70 subfamily; non-membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [118132] (73 PDB entries)
   Uniprot P43405 363-635 # structure of the SH2 domain tandem region (9-265) is also known (55576)

8. Domain d3emga_: 3emg A: [175086]
   automated match to d1xbaa_
   complexed with 685

Details for d3emga_

PDB Entry: 3emg, 2.6 Å

PDB Description: Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK)

PDB Compounds: (A:) Tyrosine-protein kinase SYK

SCOPe Domain Sequences for d3emga_:

Sequence, based on SEQRES records:

>d3emga_ d.144.1.7 (A:) Tyrosine-protein kinase SYK {Human (Homo sapiens) [TaxId: 9606]}
ldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilkneandpalkdellaeanvm
qqldnpyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmgmky
leesnfvhrdlaarnvllvtqhyakisdfglskalradenyykaqthgkwpvkwyapeci
nyykfssksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremydl
mnlcwtydvenrpgfaavelrlrnyyy

Sequence, based on observed residues (ATOM records):

>d3emga_ d.144.1.7 (A:) Tyrosine-protein kinase SYK {Human (Homo sapiens) [TaxId: 9606]}
ldrklltledkelgsgnfgtvkkgyyqmkvvktvavkilklkdellaeanvmqqldnpyi
vrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmgmkyleesnfvh
rdlaarnvllvtqhyakisdfglskalradenyykakwpvkwyapecinyykfssksdvw
sfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremydlmnlcwtydvenr
pgfaavelrlrnyyy

Timeline for d3emga_:

• d3emga_ first appeared in SCOPe 2.01
  
• d3emga_ appears in SCOPe 2.07