SCOPe 2.01: Domain d3ed7a_: 3ed7 A:

Lineage for d3ed7a_ (3ed7 A:)

1. Root: SCOPe 2.01

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
   contains large mixed beta-sheet

4. Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (1 family)

5. Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 proteins)

6. Protein automated matches [190469] (5 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [189245] (1 PDB entry)

8. Domain d3ed7a_: 3ed7 A: [174856]
   automated match to d1hvya_
   complexed with so4

Details for d3ed7a_

PDB Entry: 3ed7, 1.56 Å

PDB Description: replacement of val3 in human thymidylate synthase affects its kinetic properties and intracellular stability

PDB Compounds: (A:) Thymidylate synthase

SCOPe Domain Sequences for d3ed7a_:

Sequence, based on SEQRES records:

>d3ed7a_ d.117.1.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lxxxxpphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvf
wkgvleellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwr
hfgaeyrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcq
fyvvnselscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiyln
hieplkiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikm

Sequence, based on observed residues (ATOM records):

>d3ed7a_ d.117.1.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lxxxxpphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvf
wkgvleellwfikgstnakelsswdangsrdfldslgfstreegdlgpvygfqwrhfgae
yrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvvn
selscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiepl
kiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikm

Timeline for d3ed7a_:

• d3ed7a_ is new in SCOPe 2.01-stable
  
• d3ed7a_ appears in SCOPe 2.02
  
• d3ed7a_ appears in the current release, SCOPe 2.08