SCOPe 2.08: Domain d3dv0a_: 3dv0 A:

Lineage for d3dv0a_ (3dv0 A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

4. Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families)
   there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
   two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

5. Family c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module [88766] (5 proteins)
   parent family to TK and PFOR
   heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module

6. Protein automated matches [190098] (3 species)
   not a true protein

7. Species Bacillus stearothermophilus [TaxId:1422] [188729] (3 PDB entries)

8. Domain d3dv0a_: 3dv0 A: [174255]
   Other proteins in same PDB: d3dv0b1, d3dv0b2, d3dv0d1, d3dv0d2, d3dv0f1, d3dv0f2, d3dv0h1, d3dv0h2, d3dv0i_, d3dv0j_
   automated match to d1w85a_
   complexed with k, mg, pyr, tpw

Details for d3dv0a_

PDB Entry: 3dv0, 2.5 Å

PDB Description: Snapshots of catalysis in the E1 subunit of the pyruvate dehydrogenase multi-enzyme complex

PDB Compounds: (A:) Pyruvate dehydrogenase E1 component subunit alpha

SCOPe Domain Sequences for d3dv0a_:

Sequence, based on SEQRES records:

>d3dv0a_ c.36.1.11 (A:) automated matches {Bacillus stearothermophilus [TaxId: 1422]}
tfqfpfaeqlekvaeqfptfqilneegevvneeampelsdeqlkelmrrmvytrildqrs
islnrqgrlgfyaptagqeasqiashfalekedfilpgyrdvpqiiwhglplyqaflfsr
ghfhgnqipegvnvlppqiiigaqyiqaagvalglkmrgkkavaitytgdggtsqgdfye
ginfagafkapaifvvqnnrfaistpvekqtvaktlaqkavaagipgiqvdgmdplavya
avkaareraingegptlietlcfrygphtmsgddptryrskelenewakkdplvrfrkfl
eakglwseeeennvieqakeeikeaikkadetpkqkvtdlisimfeelpfnlkeqyeiyk
ekes

Sequence, based on observed residues (ATOM records):

>d3dv0a_ c.36.1.11 (A:) automated matches {Bacillus stearothermophilus [TaxId: 1422]}
tfqfpfaeqlekvaeqfptfqilneegevvneeampelsdeqlkelmrrmvytrildqrs
islnrqgrlgfyaptagqeasqiashfalekedfilpgyrdvpqiiwhglplyqaflfsr
ghfhgnqipegvnvlppqiiigaqyiqaagvalglkmrgkkavaitytgdggtsqgdfye
ginfagafkapaifvvqnnrfaistpvekqtvaktlaqkavaagipgiqvdgmdplavya
avkaareraingegptlietlcfrygphenewakkdplvrfrkfleakglwseeeennvi
eqakeeikeaikkadetpkqkvtdlisimfeelpfnlkeqyeiykekes

Timeline for d3dv0a_:

• d3dv0a_ first appeared in SCOPe 2.01
  
• d3dv0a_ appears in SCOPe 2.07