SCOPe 2.05: Domain d3dtwa_: 3dtw A:

Lineage for d3dtwa_ (3dtw A:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Vascular endothelial growth factor receptor 2 (kdr) [56160] (1 species)
   PTK group; PDGFR/VEGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56161] (20 PDB entries)

8. Domain d3dtwa_: 3dtw A: [174223]
   automated match to d1vr2a_
   complexed with a96

Details for d3dtwa_

PDB Entry: 3dtw, 2.9 Å

PDB Description: crystal structure of the vegfr2 kinase domain in complex with a benzisoxazole inhibitor

PDB Compounds: (A:) Vascular endothelial growth factor receptor 2

SCOPe Domain Sequences for d3dtwa_:

Sequence, based on SEQRES records:

>d3dtwa_ d.144.1.7 (A:) Vascular endothelial growth factor receptor 2 (kdr) {Human (Homo sapiens) [TaxId: 9606]}
erlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkegaths
ehralmselkilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrnefvp
ykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvkicdf
glardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgaspyp
gvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnllqan
aqqdrhhhhhh

Sequence, based on observed residues (ATOM records):

>d3dtwa_ d.144.1.7 (A:) Vascular endothelial growth factor receptor 2 (kdr) {Human (Homo sapiens) [TaxId: 9606]}
erlpydaskwefprdrlklgkplgrggqvieadafgidktcrtvavkmlkegathsehra
lmselkilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrnefvpykva
pedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvkicdflplk
wmapetifdrvytiqsdvwsfgvllweifslgaspypgvkideefcrrlkegtrmrapdy
ttpemyqtmldcwhgepsqrptfselvehlgnllqanaqqdrhhhhhh

Timeline for d3dtwa_:

• d3dtwa_ first appeared in SCOPe 2.01
  
• d3dtwa_ appears in SCOPe 2.04
  
• d3dtwa_ is called d3dtwa1 in SCOPe 2.06
  
• d3dtwa_ appears in the current release, SCOPe 2.08, called d3dtwa1