SCOPe 2.08: Domain d3dkfa1: 3dkf A:1050-1360

Lineage for d3dkfa1 (3dkf A:1050-1360)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Hepatocyte growth factor receptor, c-MET [103300] (1 species)
   PTK group; HGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [103301] (67 PDB entries)

8. Domain d3dkfa1: 3dkf A:1050-1360 [174032]
   Other proteins in same PDB: d3dkfa2
   automated match to d1r0pa_
   complexed with cl, sx8

Details for d3dkfa1

PDB Entry: 3dkf, 1.8 Å

PDB Description: structure of met receptor tyrosine kinase in complex with inhibitor sgx-523

PDB Compounds: (A:) Hepatocyte growth factor receptor

SCOPe Domain Sequences for d3dkfa1:

Sequence, based on SEQRES records:

>d3dkfa1 d.144.1.7 (A:1050-1360) Hepatocyte growth factor receptor, c-MET {Human (Homo sapiens) [TaxId: 9606]}
tvhidlsalnpelvqavqhvvigpsslivhfnevigrghfgcvyhgtlldndgkkihcav
kslnritdigevsqfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrnfi
rnethnptvkdligfglqvakgmkflaskkfvhrdlaarncmldekftvkvadfglardm
ydkefdsvhnktgaklpvkwmaleslqtqkfttksdvwsfgvllwelmtrgappypdvnt
fditvyllqgrrllqpeycpdplyevmlkcwhpkaemrpsfselvsrisaifstfigehy
vhvnatyvnvk

Sequence, based on observed residues (ATOM records):

>d3dkfa1 d.144.1.7 (A:1050-1360) Hepatocyte growth factor receptor, c-MET {Human (Homo sapiens) [TaxId: 9606]}
tvhidlsalnpelvqavqhvvigpsslivhfnevigrghfgcvyhgtlkkihcavkslnr
itdigevsqfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrnfirneth
nptvkdligfglqvakgmkflaskkfvhrdlaarncmldekftvkvadfglardmyklpv
kwmaleslqtqkfttksdvwsfgvllwelmtrgappypdvntfditvyllqgrrllqpey
cpdplyevmlkcwhpkaemrpsfselvsrisaifstfigehyvhvnatyvnvk

Timeline for d3dkfa1:

• d3dkfa1 first appeared in SCOPe 2.01, called d3dkfa_
  
• d3dkfa1 appears in SCOPe 2.07