SCOPe 2.01: Domain d3d23a_: 3d23 A:

Lineage for d3d23a_ (3d23 A:)

1. Root: SCOPe 2.01

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.4: Viral cysteine protease of trypsin fold [50603] (4 proteins)

6. Protein Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) [74979] (5 species)
   contains an extra alpha-helical domain

7. Species Human coronavirus [TaxId:443239] [188597] (1 PDB entry)

8. Domain d3d23a_: 3d23 A: [173627]
   automated match to d1uj1b_
   complexed with 3ih

Details for d3d23a_

PDB Entry: 3d23, 2.5 Å

PDB Description: main protease of hcov-hku1

PDB Compounds: (A:) 3C-like proteinase

SCOPe Domain Sequences for d3d23a_:

Sequence, based on SEQRES records:

>d3d23a_ b.47.1.4 (A:) Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) {Human coronavirus [TaxId: 443239]}
assgivkmvsptskiepcivsvtygsmtlnglwlddkvycprhvicsssnmnepdysall
crvtlgdftimsgrmsltvvsyqmqgcqlvltvslqnpytpkytfgnvkpgetftvlaay
ngrpqgafhvtmrssytikgsflcgscgsvgyvltgdsvkfvymhqlelstgchtgtdft
gnfygpyrdaqvvqlpvkdyvqtvnviawlyaailnncawfvqndvcstedfnvwamang
fsqvkadlvldalasmtgvsietllaaikrlymgfqgrqilgsctfedelapsdvyqqla
gv

Sequence, based on observed residues (ATOM records):

>d3d23a_ b.47.1.4 (A:) Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) {Human coronavirus [TaxId: 443239]}
assgivkmvsptskiepcivsvtygsmtlnglwlddkvycprhvicsmnepdysallcrv
tlgdftimsgrmsltvvsyqmqgcqlvltvslqnpytpkytfgnvkpgetftvlaayngr
pqgafhvtmrssytikgsflcgscgsvgyvltgdsvkfvymhqlelstgchtgtdftgnf
ygpyrdaqvvqlpvkdyvqtvnviawlyaailnncawfvqndvcstedfnvwamangfsq
vkadlvldalasmtgvsietllaaikrlymgfqgrqilgsctfedelapsdvyqqlagv

Timeline for d3d23a_:

• d3d23a_ is new in SCOPe 2.01-stable
  
• d3d23a_ appears in SCOPe 2.02
  
• d3d23a_ appears in the current release, SCOPe 2.08, called d3d23a1