SCOPe 2.05: Domain d3d09a_: 3d09 A:

Lineage for d3d09a_ (3d09 A:)

1. Root: SCOPe 2.05

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.2: Common fold of diphtheria toxin/transcription factors/cytochrome f [49379] (9 superfamilies)
   sandwich; 9 strands in 2 sheet; greek-key; subclass of immunoglobin-like fold

4. Superfamily b.2.5: p53-like transcription factors [49417] (8 families)

5. Family b.2.5.2: p53 DNA-binding domain-like [81314] (3 proteins)

6. Protein p53 tumor suppressor, DNA-binding domain [49419] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [49420] (34 PDB entries)

8. Domain d3d09a_: 3d09 A: [173593]
   automated match to d1gzha_
   complexed with zn; mutant

Details for d3d09a_

PDB Entry: 3d09, 1.9 Å

PDB Description: human p53 core domain with hot spot mutation r249s and second-site suppressor mutations h168r and t123a

PDB Compounds: (A:) Cellular tumor antigen p53

SCOPe Domain Sequences for d3d09a_:

Sequence, based on SEQRES records:

>d3d09a_ b.2.5.2 (A:) p53 tumor suppressor, DNA-binding domain {Human (Homo sapiens) [TaxId: 9606]}
svpsqktyqgsygfrlgflhsgtaksvactyspalnkmfcqlaktcpvqlwvdstpppgt
rvramaiykqsqrmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfrhs
vvvpyeppevgsdcttihynymcnsscmggmnrspiltiitledssgnllgrnsfevrvc
acpgrdrrteeenlr

Sequence, based on observed residues (ATOM records):

>d3d09a_ b.2.5.2 (A:) p53 tumor suppressor, DNA-binding domain {Human (Homo sapiens) [TaxId: 9606]}
svpsqktyqgsygfrlgflhsvactyspalnkmfcqlaktcpvqlwvdstpppgtrvram
aiykqsqrmtevvrrcphhercsdglappqhlirvegnlrveylddrntfrhsvvvpyep
pevgsdcttihynymcnsscmggmnrspiltiitledssgnllgrnsfevrvcacpgrdr
rteeenlr

Timeline for d3d09a_:

• d3d09a_ first appeared in SCOPe 2.01
  
• d3d09a_ appears in SCOPe 2.04
  
• d3d09a_ appears in SCOPe 2.06
  
• d3d09a_ appears in the current release, SCOPe 2.08