SCOPe 2.07: Domain d3ctqa_: 3ctq A:

Lineage for d3ctqa_ (3ctq A:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein MAP kinase p38 [56129] (2 species)
   CMGC group; ERK/MAPK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56130] (202 PDB entries)

8. Domain d3ctqa_: 3ctq A: [173462]
   automated match to d1a9ua_
   complexed with 337

Details for d3ctqa_

PDB Entry: 3ctq, 1.95 Å

PDB Description: Structure of MAP kinase p38 in complex with a 1-o-tolyl-1,2,3-triazole-4-carboxamide

PDB Compounds: (A:) Mitogen-activated protein kinase 14

SCOPe Domain Sequences for d3ctqa_:

Sequence, based on SEQRES records:

>d3ctqa_ d.144.1.7 (A:) MAP kinase p38 {Human (Homo sapiens) [TaxId: 9606]}
rptfyrqelaktiwevperyqnlspvgsgaygsvcaafdtktghrvavkklsrpfqsiih
akrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcakltd
dhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglarhtddemtgyva
trwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpga
ellkkissesarnyiqslaqmpkmnfanvfiganplavdllekmlvldsdkritaaqala
hayfaqyhdpddepvadpydqsfesrdllidewksltydevisfvppp

Sequence, based on observed residues (ATOM records):

>d3ctqa_ d.144.1.7 (A:) MAP kinase p38 {Human (Homo sapiens) [TaxId: 9606]}
rptfyrqelaktiwevperyqnlspvgsgaygsvcaafdtktghrvavkklsrpfqsiih
akrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcakltd
dhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfgvatrwyrapeimln
wmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpgaellkkissesar
nyiqslaqmpkmnfanvfiganplavdllekmlvldsdkritaaqalahayfaqyhdpdd
epvadpydqsfesrdllidewksltydevisfvppp

Timeline for d3ctqa_:

• d3ctqa_ first appeared in SCOPe 2.01
  
• d3ctqa_ appears in SCOPe 2.06
  
• d3ctqa_ appears in the current release, SCOPe 2.08