SCOPe 2.04: Domain d3c0aa_: 3c0a A:

Lineage for d3c0aa_ (3c0a A:)

1. Root: SCOPe 2.04

2. Class d: Alpha and beta proteins (a+b) [53931] (380 folds)

3. Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
   contains large mixed beta-sheet

4. Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (2 families)
   automatically mapped to Pfam PF00303

5. Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 proteins)

6. Protein Thymidylate synthase [55833] (7 species)

7. Species Lactobacillus casei [TaxId:1582] [55835] (51 PDB entries)

8. Domain d3c0aa_: 3c0a A: [172972]
   automated match to d1bo7a_
   complexed with 14c, ump

Details for d3c0aa_

PDB Entry: 3c0a, 2.4 Å

PDB Description: Lactobacillus CASEI Thymidylate Synthase Ternary Complex with DUMP and the Phtalimidic Derivative 14C in Multiple Binding Modes-Mode 2

PDB Compounds: (A:) Thymidylate synthase

SCOPe Domain Sequences for d3c0aa_:

Sequence, based on SEQRES records:

>d3c0aa_ d.117.1.1 (A:) Thymidylate synthase {Lactobacillus casei [TaxId: 1582]}
mleqpyldlakkvldeghfkpdrthtgtysifghqmrfdlskgfpllttkkvpfglikse
llwflhgdtnirfllqhrnhiwdewafekwvksdeyhgpdmtdfghrsqkdpefaavyhe
emakfddrvlhddafaakygdlglvygsqwrawhtskgdtidqlgdvieqikthpysrrl
ivsawnpedvptmalppchtlyqfyvndgklslqlyqrsadiflgvpfniasyallthlv
ahecglevgefihtfgdahlyvnhldqikeqlsrtprpaptlqlnpdkhdifdfdmkdik
llnydpypaikap

Sequence, based on observed residues (ATOM records):

>d3c0aa_ d.117.1.1 (A:) Thymidylate synthase {Lactobacillus casei [TaxId: 1582]}
mleqpyldlakkvldeghfkptgtysifghqmrfdlskgfpllttkkvpfgliksellwf
lhgdtnirfllqhrnhiwdewafekwvksdeyhyheemakfddrvlhddafaakygdlgl
vygsqwrawhtskgdtidqlgdvieqikthpysrrlivsawnpedvptmalppchtlyqf
yvndgklslqlyqrsadiflgvpfniasyallthlvahecglevgefihtfgdahlyvnh
ldqikeqlsrtprpaptlqlnpdkhdifdfdmkdikllnydpypaikap

Timeline for d3c0aa_:

• d3c0aa_ first appeared in SCOPe 2.01
  
• d3c0aa_ appears in SCOPe 2.03
  
• d3c0aa_ appears in SCOPe 2.05
  
• d3c0aa_ appears in the current release, SCOPe 2.08