SCOPe 2.01: Domain d3braa_: 3bra A:

Lineage for d3braa_ (3bra A:)

1. Root: SCOPe 2.01

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein automated matches [190156] (3 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187237] (29 PDB entries)

8. Domain d3braa_: 3bra A: [172798]
   automated match to d1fkna_
   complexed with aef

Details for d3braa_

PDB Entry: 3bra, 2.3 Å

PDB Description: bace-1 complexed with compound 1

PDB Compounds: (A:) Beta-secretase 1

SCOPe Domain Sequences for d3braa_:

Sequence, based on SEQRES records:

>d3braa_ b.50.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
rgsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrq
lsstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnw
egilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmi
iggidhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlr
lpkkvfeaavasikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqs
fritilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfa
vsachvhdefrtaavegpfvtldmedcgyni

Sequence, based on observed residues (ATOM records):

>d3braa_ b.50.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
rgsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrq
lsstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnw
egilglayaeiarpddslepffdslvkqthvpnlfslqlcgsvggsmiiggidhslytgs
lwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaavas
ikaasstefpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfritilpqqylrp
vdcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsachvhdefrtaavegpfvt
ldmedcgyni

Timeline for d3braa_:

• d3braa_ is new in SCOPe 2.01-stable
  
• d3braa_ appears in SCOPe 2.02
  
• d3braa_ appears in the current release, SCOPe 2.08