SCOPe 2.03: Domain d3bpfa_: 3bpf A:

Lineage for d3bpfa_ (3bpf A:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.3: Cysteine proteinases [54000] (1 superfamily)
   consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn

4. Superfamily d.3.1: Cysteine proteinases [54001] (23 families)
   the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet

5. Family d.3.1.1: Papain-like [54002] (26 proteins)

6. Protein Falcipain 2 [142846] (1 species)

7. Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [142847] (5 PDB entries)
   Uniprot Q9N6S8 244-484

8. Domain d3bpfa_: 3bpf A: [172767]
   automated match to d1yvba1
   complexed with e64, gol

Details for d3bpfa_

PDB Entry: 3bpf, 2.9 Å

PDB Description: Crystal Structure of Falcipain-2 with Its inhibitor, E64

PDB Compounds: (A:) Cysteine protease falcipain-2

SCOPe Domain Sequences for d3bpfa_:

Sequence, based on SEQRES records:

>d3bpfa_ d.3.1.1 (A:) Falcipain 2 {Malaria parasite (Plasmodium falciparum) [TaxId: 5833]}
qmnyeevikkyrgeenfdhaaydwrlhsgvtpvkdqkncgscwafssigsvesqyairkn
klitlseqelvdcsfknygcngglinnafedmielggicpdgdypyvsdapnlcnidrct
ekygiknylsvpdnklkealrflgpisisvavsddfafykegifdgecgdqlnhavmlvg
fgmkeivnpltkkgekhyyyiiknswgqqwgergfinietdesglmrkcglgtdafipli
e

Sequence, based on observed residues (ATOM records):

>d3bpfa_ d.3.1.1 (A:) Falcipain 2 {Malaria parasite (Plasmodium falciparum) [TaxId: 5833]}
qmnyeevikkyrgeenfdhaaydwrlhsgvtpvkdqkncgscwafssigsvesqyairkn
klitlseqelvdcsfknygcngglinnafedmielggicpdgdypyvsdapnlcnidrct
ekygiknylsvpdnklkealrflgpisisvavsddfafykegifdgecgdqlnhavmlvg
fgmkeivngekhyyyiiknswgqqwgergfinietdesglmrkcglgtdafiplie

Timeline for d3bpfa_:

• d3bpfa_ first appeared in SCOPe 2.01
  
• d3bpfa_ appears in SCOPe 2.02
  
• d3bpfa_ appears in SCOPe 2.04
  
• d3bpfa_ appears in the current release, SCOPe 2.08