SCOPe 2.05: Domain d3am4a_: 3am4 A:

Lineage for d3am4a_ (3am4 A:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein Enoyl-ACP reductase [51791] (11 species)

7. Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [82296] (23 PDB entries)
   Uniprot Q9BJJ9 96-424 # fragment

8. Domain d3am4a_: 3am4 A: [172240]
   automated match to d1uh5a_
   complexed with ft1, nad; mutant

Details for d3am4a_

PDB Entry: 3am4, 2.3 Å

PDB Description: A372M mutant of Enoyl-ACP Reductase from Plasmodium falciparum (PfENR) in complex with triclosan variant T1

PDB Compounds: (A:) Enoyl-ACP reductase

SCOPe Domain Sequences for d3am4a_:

Sequence, based on SEQRES records:

>d3am4a_ c.2.1.2 (A:) Enoyl-ACP reductase {Malaria parasite (Plasmodium falciparum) [TaxId: 5833]}
nedicfiagigdtngygwgiakelskrnvkiifgiwppvynifmknykngkfdndmiidk
dkkmnildmlpfdasfdtandideetknnkrynmlqnytiedvanlihqkygkinmlvhs
lanakevqkdllntsrkgyldalskssyslislckyfvnimkpqssiisltyhasqkvvp
gygggmssakaalesdtrvlayhlgrnynirintisagplksraatainklnntyenntn
qnknrnrhdvhnimnnsgekeekkisasqnytfidymieysekyaplrqkllstdigsva
sfllsresraitgqtiyvdnglnimflpd

Sequence, based on observed residues (ATOM records):

>d3am4a_ c.2.1.2 (A:) Enoyl-ACP reductase {Malaria parasite (Plasmodium falciparum) [TaxId: 5833]}
nedicfiagigdtngygwgiakelskrnvkiifgiwppvynifmknykngkfdndmiidk
dkkmnildmlpfdasfdtandideetknnkrynmlqnytiedvanlihqkygkinmlvhs
lanakevqkdllntsrkgyldalskssyslislckyfvnimkpqssiisltyhasqkvvp
gygggmssakaalesdtrvlayhlgrnynirintisagplksraataintfidymieyse
kyaplrqkllstdigsvasfllsresraitgqtiyvdnglnimflpd

Timeline for d3am4a_:

• d3am4a_ first appeared in SCOPe 2.01
  
• d3am4a_ appears in SCOPe 2.04
  
• d3am4a_ appears in SCOPe 2.06
  
• d3am4a_ appears in the current release, SCOPe 2.08