SCOPe 2.02: Domain d2zjha_: 2zjh A:

Lineage for d2zjha_ (2zjh A:)

1. Root: SCOPe 2.02

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein beta-secretase (memapsin) [50671] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50672] (139 PDB entries)
   Uniprot P56817 58-446 ! Uniprot P56817 60-447

8. Domain d2zjha_: 2zjh A: [171246]
   automated match to d1fkna_
   complexed with f1h

Details for d2zjha_

PDB Entry: 2zjh, 2.6 Å

PDB Description: crystal structure of the human bace1 catalytic domain in complex with n-(1-benzyl-piperidin-4-yl)-4-mercapto-butyramide

PDB Compounds: (A:) Beta-secretase 1

SCOPe Domain Sequences for d2zjha_:

Sequence, based on SEQRES records:

>d2zjha_ b.50.1.2 (A:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
gsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrql
sstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwe
gilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmii
ggidhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrl
pkkvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsf
ritilpqqylrpvedvatsqddcykfaisqsstgtcmgavimegfyvvfdrarkrigfav
sachvhdefrtaavegpfvtldmedcgyn

Sequence, based on observed residues (ATOM records):

>d2zjha_ b.50.1.2 (A:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
gsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrql
sstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwe
gilglayaeiarpddslepffdslvkqthvpnlfslqlcgavggsmiiggidhslytgsl
wytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaavksi
kaasstekfpdgfwlgeqlvfpvislylmgevtnqsfritilpqqylrpvykfaisqsst
gtcmgavimegfyvvfdrarkrigfavsachvhdefrtaavegpfvtldmedcgyn

Timeline for d2zjha_:

• d2zjha_ first appeared in SCOPe 2.01
  
• d2zjha_ appears in SCOPe 2.03
  
• d2zjha_ appears in the current release, SCOPe 2.08