SCOPe 2.06: Domain d2ydja_: 2ydj A:

Lineage for d2ydja_ (2ydj A:)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cell cycle checkpoint kinase chk1 [64404] (1 species)
   CaMK group; CAMKL subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [64405] (66 PDB entries)

8. Domain d2ydja_: 2ydj A: [170763]
   automated match to d1ia8a_
   complexed with po4, ydj

Details for d2ydja_

PDB Entry: 2ydj, 1.85 Å

PDB Description: discovery of checkpoint kinase inhibitor azd7762 by structure based design and optimization of thiophene carboxamide ureas

PDB Compounds: (A:) Serine/threonine-protein kinase Chk1

SCOPe Domain Sequences for d2ydja_:

Sequence, based on SEQRES records:

>d2ydja_ d.144.1.7 (A:) Cell cycle checkpoint kinase chk1 {Human (Homo sapiens) [TaxId: 9606]}
dwdlvqtlgegaygevqlavnrvteeavavkivdmkravdcpenikkeicinkmlnhenv
vkfyghrregniqylfleycsggelfdriepdigmpepdaqrffhqlmagvvylhgigit
hrdikpenlllderdnlkisdfglatvfrynnrerllnkmcgtlpyvapellkrrefhae
pvdvwscgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplallhkilv
enpsaritipdikkdrwynkpl

Sequence, based on observed residues (ATOM records):

>d2ydja_ d.144.1.7 (A:) Cell cycle checkpoint kinase chk1 {Human (Homo sapiens) [TaxId: 9606]}
dwdlvqtlgegaygevqlavnrvteeavavkivdmnikkeicinkmlnhenvvkfyghrr
egniqylfleycsggelfdriepdigmpepdaqrffhqlmagvvylhgigithrdikpen
lllderdnlkisdfglatvfrynnrerllnkmcgtlpyvapellkrrefhaepvdvwscg
ivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplallhkilvenpsarit
ipdikkdrwynkpl

Timeline for d2ydja_:

• d2ydja_ first appeared in SCOPe 2.01
  
• d2ydja_ appears in SCOPe 2.05
  
• d2ydja_ appears in SCOPe 2.07
  
• d2ydja_ appears in the current release, SCOPe 2.08