SCOPe 2.07: Domain d2xxia1: 2xxi A:3-263

Lineage for d2xxia1 (2xxi A:3-263)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.94: Periplasmic binding protein-like II [53849] (1 superfamily)
   consists of two similar intertwined domain with 3 layers (a/b/a) each: duplication
   mixed beta-sheet of 5 strands, order 21354; strand 5 is antiparallel to the rest

4. Superfamily c.94.1: Periplasmic binding protein-like II [53850] (4 families)
   Similar in architecture to the superfamily I but partly differs in topology

5. Family c.94.1.1: Phosphate binding protein-like [53851] (45 proteins)

6. Protein Glutamate receptor ligand binding core [53881] (5 species)

7. Species Norway rat (Rattus norvegicus), GluR2 [TaxId:10116] [53882] (157 PDB entries)

8. Domain d2xxia1: 2xxi A:3-263 [170469]
   Other proteins in same PDB: d2xxia2, d2xxib2
   automated match to d1lbcb_
   complexed with glu, jac, so4, zn

Details for d2xxia1

PDB Entry: 2xxi, 1.6 Å

PDB Description: crystal structure of 1-((4-(3-(trifluoromethyl)-6,7-dihydropyrano(4,3 -c(pyrazol-1(4h)-yl)phenyl)methyl)-2-pyrrolidinone in complex with the ligand binding domain of the rat glua2 receptor and glutamate at 1.6a resolution.

PDB Compounds: (A:) Glutamate receptor 2

SCOPe Domain Sequences for d2xxia1:

Sequence; same for both SEQRES and ATOM records:

>d2xxia1 c.94.1.1 (A:3-263) Glutamate receptor ligand binding core {Norway rat (Rattus norvegicus), GluR2 [TaxId: 10116]}
nktvvvttilespyvmmkknhemlegneryegycvdlaaeiakhcgfkykltivgdgkyg
ardadtkiwngmvgelvygkadiaiapltitlvreevidfskpfmslgisimikkgtpie
saedlskqteiaygtldsgstkeffrrskiavfdkmwtymrsaepsvfvrttaegvarvr
kskgkyayllestmneyieqrkpcdtmkvggnldskgygiatpkgsslgnavnlavlkls
eqglldklknkwwydkgecgs

Timeline for d2xxia1:

• d2xxia1 first appeared in SCOPe 2.01, called d2xxia_
  
• d2xxia1 appears in SCOPe 2.06
  
• d2xxia1 appears in the current release, SCOPe 2.08