SCOPe 2.04: Domain d2xoxa_: 2xox A:

Lineage for d2xoxa_ (2xox A:)

1. Root: SCOPe 2.04

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein automated matches [190085] (43 species)
   not a true protein

7. Species Leishmania donovani [TaxId:5661] [189607] (1 PDB entry)

8. Domain d2xoxa_: 2xox A: [170265]
   automated match to d1e7wa_
   complexed with so4

Details for d2xoxa_

PDB Entry: 2xox, 2.5 Å

PDB Description: crystal structure of pteridine reductase (ptr1) from leishmania donovani

PDB Compounds: (A:) pteridine reductase

SCOPe Domain Sequences for d2xoxa_:

Sequence, based on SEQRES records:

>d2xoxa_ c.2.1.2 (A:) automated matches {Leishmania donovani [TaxId: 5661]}
tvpvalvtgaakrlgsgiaeglhaegyavclhyhrsaaeantlaatlnarrpnsaipvqa
dlsnvakapaggadgaapvtlfkrcadlvaacythwgrcdvlvnnassfyptpllrkded
ghvpcvgdreameaaaadlfgsnamapyflikafahrvadtpaeqrgtnysivnmvdamt
sqpllgytiytmakgalegltrsaalelaplqirvngvgpglsvladdmppavredyrsk
vplyqrdssaaevsdvviflcsskakyvtgtcvkvd

Sequence, based on observed residues (ATOM records):

>d2xoxa_ c.2.1.2 (A:) automated matches {Leishmania donovani [TaxId: 5661]}
tvpvalvtgaakrlgsgiaeglhaegyavclhyhrsaaeantlaatlnarrpnsaipvqa
dlsnvapvtlfkrcadlvaacythwgrcdvlvnnasreameaaaadlfgsnamapyflik
afahrvadtpaeqrgtnysivnmvdamtsqpllgytiytmakgalegltrsaalelaplq
irvngvgpglaevsdvviflcsskakyvtgtcvkvd

Timeline for d2xoxa_:

• d2xoxa_ first appeared in SCOPe 2.01
  
• d2xoxa_ appears in SCOPe 2.03
  
• d2xoxa_ appears in SCOPe 2.05
  
• d2xoxa_ appears in the current release, SCOPe 2.08