SCOPe 2.06: Domain d2xnea_: 2xne A:

Lineage for d2xnea_ (2xne A:)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (17 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (653 PDB entries)

8. Domain d2xnea_: 2xne A: [170251]
   automated match to d1ol5a_
   complexed with ash

Details for d2xnea_

PDB Entry: 2xne, 2.8 Å

PDB Description: structure of aurora-a bound to an imidazopyrazine inhibitor

PDB Compounds: (A:) serine/threonine-protein kinase 6

SCOPe Domain Sequences for d2xnea_:

Sequence, based on SEQRES records:

>d2xnea_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
qwaledfeigrplgkgkfgnvylarekqskfilalkvlfkaqlekagvehqlrreveiqs
hlrhpnilrlygyfhdatrvylileyaplgtvyrelqklskfdeqrtatyitelanalsy
chskrvihrdikpenlllgsagelkianfgwsvhapssrrttlcgtldylppemiegrmh
dekvdlwslgvlcyeflvgkppfeantyqetykrisrveftfpdfvtegardlisrllkh
npsqrpmlrevlehpwitanss

Sequence, based on observed residues (ATOM records):

>d2xnea_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
qwaledfeigrplgkgkfgnvylarekqskfilalkvlfgvehqlrreveiqshlrhpni
lrlygyfhdatrvylileyaplgtvyrelqklskfdeqrtatyitelanalsychskrvi
hrdikpenlllgsagelkianfgwsvhaptldylppemiegrmhdekvdlwslgvlcyef
lvgkppfeantyqetykrisrveftfpdfvtegardlisrllkhnpsqrpmlrevlehpw
itanss

Timeline for d2xnea_:

• d2xnea_ first appeared in SCOPe 2.01
  
• d2xnea_ appears in SCOPe 2.05
  
• d2xnea_ appears in SCOPe 2.07
  
• d2xnea_ appears in the current release, SCOPe 2.08