SCOPe 2.02: Domain d2xkea_: 2xke A:

Lineage for d2xkea_ (2xke A:)

1. Root: SCOPe 2.02

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (10 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (293 PDB entries)

8. Domain d2xkea_: 2xke A: [170177]
   automated match to d2java1
   complexed with cl, wi2

Details for d2xkea_

PDB Entry: 2xke, 2.2 Å

PDB Description: structure of nek2 bound to aminipyrazine compound 5

PDB Compounds: (A:) serine/threonine-protein kinase nek2

SCOPe Domain Sequences for d2xkea_:

Sequence, based on SEQRES records:

>d2xkea_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
sraedyevlytigtgsygrcqkirrksdgkilvwkeldygsmteaekqmlvsevnllrel
khpnivryydriidrtnttlyivmeyceggdlasvitkgtkerqyldeefvlrvmtqltl
alkechrrsdgghtvlhrdlkpanvfldgkqnvklgdfglarilnhdtsfaktfvgtpyy
mspeqmnrmsyneksdiwslgcllyelcalmppftafsqkelagkiregkfrripyrysd
elneiitrmlnlkdyhrpsveeilenplilehhhhhh

Sequence, based on observed residues (ATOM records):

>d2xkea_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
sraedyevlytigtgrcqkirrksdgkilvwkeldygsmteaekqmlvsevnllrelkhp
nivryydriidrtnttlyivmeyceggdlasvitkgtkerqyldeefvlrvmtqltlalk
echrrsdlkpanvfldgkqnvklgdftpyymspeqmnneksdiwslgcllyelcalmppf
tafsqkelagkiregkfrripyrysdelneiitrmlnlkdyhrpsveeilenplilehhh
hhh

Timeline for d2xkea_:

• d2xkea_ first appeared in SCOPe 2.01
  
• d2xkea_ appears in SCOPe 2.03
  
• d2xkea_ appears in the current release, SCOPe 2.08, called d2xkea1