SCOPe 2.04: Domain d2xk8a_: 2xk8 A:

Lineage for d2xk8a_ (2xk8 A:)

1. Root: SCOPe 2.04

2. Class d: Alpha and beta proteins (a+b) [53931] (380 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (13 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (490 PDB entries)

8. Domain d2xk8a_: 2xk8 A: [170174]
   automated match to d2java1
   complexed with 5r1, cl

Details for d2xk8a_

PDB Entry: 2xk8, 2 Å

PDB Description: structure of nek2 bound to aminopyrazine compound 15

PDB Compounds: (A:) serine/threonine-protein kinase nek2

SCOPe Domain Sequences for d2xk8a_:

Sequence, based on SEQRES records:

>d2xk8a_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
sraedyevlytigtgsygrcqkirrksdgkilvwkeldygsmteaekqmlvsevnllrel
khpnivryydriidrtnttlyivmeyceggdlasvitkgtkerqyldeefvlrvmtqltl
alkechrrsdgghtvlhrdlkpanvfldgkqnvklgdfglarilnhdtsfaktfvgtpyy
mspeqmnrmsyneksdiwslgcllyelcalmppftafsqkelagkiregkfrripyrysd
elneiitrmlnlkdyhrpsveeilenplilehhhhhh

Sequence, based on observed residues (ATOM records):

>d2xk8a_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
sraedyevlytigtrcqkirrksdgkilvwkeldygsmteaekqmlvsevnllrelkhpn
ivryydriidrtnttlyivmeyceggdlasvitkgtkerqyldeefvlrvmtqltlalke
chrrsrdlkpanvfldgkqnvklgdffvgtpyymspeqmnneksdiwslgcllyelcalm
ppftafsqkelagkiregkfrripyrysdelneiitrmlnlkdyhrpsveeilenplile
hhhhhh

Timeline for d2xk8a_:

• d2xk8a_ first appeared in SCOPe 2.01
  
• d2xk8a_ appears in SCOPe 2.03
  
• d2xk8a_ appears in SCOPe 2.05
  
• d2xk8a_ appears in the current release, SCOPe 2.08, called d2xk8a1