SCOPe 2.01: Domain d2xf0a_: 2xf0 A:

Lineage for d2xf0a_ (2xf0 A:)

1. Root: SCOPe 2.01

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (8 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (254 PDB entries)

8. Domain d2xf0a_: 2xf0 A: [170077]
   automated match to d1ia8a_
   protein/DNA complex; complexed with 4ub, edo

Details for d2xf0a_

PDB Entry: 2xf0, 2.4 Å

PDB Description: crystal structure of checkpoint kinase 1 (chk1) in complex with inhibitors

PDB Compounds: (A:) Serine/threonine-protein kinase Chk1

SCOPe Domain Sequences for d2xf0a_:

Sequence, based on SEQRES records:

>d2xf0a_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
pfvedwdlvqtlgegaygevqlavnrvteeavavkivdmkravdcpenikkeicinkmln
henvvkfyghrregniqylfleycsggelfdriepdigmpepdaqrffhqlmagvvylhg
igithrdikpenlllderdnlkisdfglatvfrynnrerllnkmcgtlpyvapellkrre
fhaepvdvwscgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplallh
kilvenpsaritipdikkdrwynkplk

Sequence, based on observed residues (ATOM records):

>d2xf0a_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
pfvedwdlvqtlgevqlavnrvteeavavkivdnikkeicinkmlnhenvvkfyghrrei
qylfleycsggelfdriepdigmpepdaqrffhqlmagvvylhgigithrdikpenllld
erdnlkisdfglatvfrynnrerllnkmcgtlpyvapellkrrefhaepvdvwscgivlt
amlagelpwdqpsdscqeysdwkekktylnpwkkidsaplallhkilvenpsaritipdi
kkdrwynkplk

Timeline for d2xf0a_:

• d2xf0a_ is new in SCOPe 2.01-stable
  
• d2xf0a_ appears in SCOPe 2.02
  
• d2xf0a_ appears in the current release, SCOPe 2.08