Lineage for d2x8ea_ (2x8e A:)

  1. Root: SCOPe 2.06
  2. 2170735Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2218047Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2218048Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2218179Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 2218680Protein Cell cycle checkpoint kinase chk1 [64404] (1 species)
    CaMK group; CAMKL subfamily; serine/threonine kinase
  7. 2218681Species Human (Homo sapiens) [TaxId:9606] [64405] (66 PDB entries)
  8. 2218746Domain d2x8ea_: 2x8e A: [169945]
    automated match to d1ia8a_
    complexed with so4, x8e

Details for d2x8ea_

PDB Entry: 2x8e (more details), 2.5 Å

PDB Description: discovery of a novel class of triazolones as checkpoint kinase inhibitors - hit to lead exploration
PDB Compounds: (A:) Serine/threonine-protein kinase Chk1

SCOPe Domain Sequences for d2x8ea_:

Sequence, based on SEQRES records: (download)

>d2x8ea_ d.144.1.7 (A:) Cell cycle checkpoint kinase chk1 {Human (Homo sapiens) [TaxId: 9606]}
wdlvqtlgegaygevqlavnrvteeavavkivdmkravdcpenikkeicinkmlnhenvv
kfyghrregniqylfleycsggelfdriepdigmpepdaqrffhqlmagvvylhgigith
rdikpenlllderdnlkisdfglatvfrynnrerllnkmcgtlpyvapellkrrefhaep
vdvwscgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplallhkilve
npsaritipdikkdrwynkplk

Sequence, based on observed residues (ATOM records): (download)

>d2x8ea_ d.144.1.7 (A:) Cell cycle checkpoint kinase chk1 {Human (Homo sapiens) [TaxId: 9606]}
wdlvqtlgegaygevqlavnrvteeavavkivdmkrcpenikkeicinkmlnhenvvkfy
ghrregniqylfleycsggelfdriepdigmpepdaqrffhqlmagvvylhgigithrdi
kpenlllderdnlkisdfglatvfrynnrerllnkmcgtlpyvapellkrrefhaepvdv
wscgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplallhkilvenps
aritipdikkdrwynkplk

SCOPe Domain Coordinates for d2x8ea_:

Click to download the PDB-style file with coordinates for d2x8ea_.
(The format of our PDB-style files is described here.)

Timeline for d2x8ea_: