SCOPe 2.03: Domain d2x8ea_: 2x8e A:

Lineage for d2x8ea_ (2x8e A:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cell cycle checkpoint kinase chk1 [64404] (1 species)
   CaMK group; CAMKL subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [64405] (70 PDB entries)

8. Domain d2x8ea_: 2x8e A: [169945]
   automated match to d1ia8a_
   complexed with so4, x8e

Details for d2x8ea_

PDB Entry: 2x8e, 2.5 Å

PDB Description: discovery of a novel class of triazolones as checkpoint kinase inhibitors - hit to lead exploration

PDB Compounds: (A:) Serine/threonine-protein kinase Chk1

SCOPe Domain Sequences for d2x8ea_:

Sequence, based on SEQRES records:

>d2x8ea_ d.144.1.7 (A:) Cell cycle checkpoint kinase chk1 {Human (Homo sapiens) [TaxId: 9606]}
wdlvqtlgegaygevqlavnrvteeavavkivdmkravdcpenikkeicinkmlnhenvv
kfyghrregniqylfleycsggelfdriepdigmpepdaqrffhqlmagvvylhgigith
rdikpenlllderdnlkisdfglatvfrynnrerllnkmcgtlpyvapellkrrefhaep
vdvwscgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplallhkilve
npsaritipdikkdrwynkplk

Sequence, based on observed residues (ATOM records):

>d2x8ea_ d.144.1.7 (A:) Cell cycle checkpoint kinase chk1 {Human (Homo sapiens) [TaxId: 9606]}
wdlvqtlgegaygevqlavnrvteeavavkivdmkrcpenikkeicinkmlnhenvvkfy
ghrregniqylfleycsggelfdriepdigmpepdaqrffhqlmagvvylhgigithrdi
kpenlllderdnlkisdfglatvfrynnrerllnkmcgtlpyvapellkrrefhaepvdv
wscgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplallhkilvenps
aritipdikkdrwynkplk

Timeline for d2x8ea_:

• d2x8ea_ first appeared in SCOPe 2.01
  
• d2x8ea_ appears in SCOPe 2.02
  
• d2x8ea_ appears in SCOPe 2.04
  
• d2x8ea_ appears in the current release, SCOPe 2.08