SCOPe 2.03: Domain d2x2la_: 2x2l A:

Lineage for d2x2la_ (2x2l A:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (18 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (314 PDB entries)

8. Domain d2x2la_: 2x2l A: [169828]
   automated match to d1agwb_
   complexed with fmt, x2l

Details for d2x2la_

PDB Entry: 2x2l, 2 Å

PDB Description: crystal structure of phosphorylated ret tyrosine kinase domain with inhibitor

PDB Compounds: (A:) proto-oncogene tyrosine-protein kinase receptor ret

SCOPe Domain Sequences for d2x2la_:

Sequence, based on SEQRES records:

>d2x2la_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
gplslsvdafkiledpkwefprknlvlgktlgegefgkvvkatafhlkgragyttvavkm
lkenaspselrdllsefnvlkqvnhphviklygacsqdgpllliveyakygslrgflres
rkvgpgylgsggsrnsssldhpderaltmgdlisfawqisqgmqylaemklvhrdlaarn
ilvaegrkmkisdfglsrdvyeedsyvkrsqgripvkwmaieslfdhiyttqsdvwsfgv
llweivtlggnpypgipperlfnllktghrmerpdncseemyrlmlqcwkqepdkrpvfa
diskdlekmmv

Sequence, based on observed residues (ATOM records):

>d2x2la_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
gplslsvdafkilpkwefprknlvlgktlgegefgkvvkatafhlkgragyttvavkmlk
enaspselrdllsefnvlkqvnhphviklygacsqdgpllliveyakygslrgflresrk
vraltmgdlisfawqisqgmqylaemklvhrdlaarnilvaegrkmkisdfglsrdvyee
dsyvkrsqgripvkwmaieslfdhiyttqsdvwsfgvllweivtlggnpypgipperlfn
llktghrmerpdncseemyrlmlqcwkqepdkrpvfadiskdlekmmv

Timeline for d2x2la_:

• d2x2la_ first appeared in SCOPe 2.01
  
• d2x2la_ appears in SCOPe 2.02
  
• d2x2la_ appears in SCOPe 2.04
  
• d2x2la_ appears in the current release, SCOPe 2.08, called d2x2la1